Author: Moss, Ronald B
Title: Prospects for control of emerging infectious diseases with plasmid DNA vaccines Document date: 2009_9_7
ID: 1a5u7uux_25
Snippet: Needle and syringe is the predominant method to deliver both DNA vaccines as well as conventional vaccines. However, Roy and colleagues at PowderMed (now Pfizer Incorporated) have used DNA precipitated onto gold particles which are driven into to skin with a blast of pressurized gas, and called this approach "particle-mediated epidermal delivery" (PMED). In one clinical study by Roy and collaborators using PMED, individuals exhibited potent antib.....
Document: Needle and syringe is the predominant method to deliver both DNA vaccines as well as conventional vaccines. However, Roy and colleagues at PowderMed (now Pfizer Incorporated) have used DNA precipitated onto gold particles which are driven into to skin with a blast of pressurized gas, and called this approach "particle-mediated epidermal delivery" (PMED). In one clinical study by Roy and collaborators using PMED, individuals exhibited potent antibody responses to a hepatitis B DNA vaccine [19] . In another study, Drape and colleagues at Pow-derMed also observed strong antibody responses to the influenza virus DNA vaccine with the PMED approach [20] .
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