Author: Hershenson, Marc B.
Title: Rhinovirus-Induced Exacerbations of Asthma and COPD Document date: 2013_2_21
ID: 1kdc6xk8_7
Snippet: Until recently there was little evidence that rhinovirus replication occurred in the lower airways. However, the Wisconsin group [35] , examining sputum of experimentally infected controls and adults, showed persistence of viral RNA up to 14 days after infection; this duration of infection could only occur with viral replication. (Nevertheless, the amount of viral replication in the airways remains uncertain.) Also, patients with asthma who had a.....
Document: Until recently there was little evidence that rhinovirus replication occurred in the lower airways. However, the Wisconsin group [35] , examining sputum of experimentally infected controls and adults, showed persistence of viral RNA up to 14 days after infection; this duration of infection could only occur with viral replication. (Nevertheless, the amount of viral replication in the airways remains uncertain.) Also, patients with asthma who had an exacerbation following experimental infection had higher levels of viral RNA in their sputum compared to asthmatics that did not experience an exacerbation, further evidence that viruses do indeed cause exacerbations.
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