Author: Wang, Li; Xia, Tian; Guo, Tiantian; Ru, Yi; Jiang, Yanping; Cui, Wen; Zhou, Han; Qiao, Xinyuan; Tang, Lijie; Xu, Yigang; Li, Yijing
Title: Recombinant Lactobacillus casei Expressing Capsid Protein VP60 can Serve as Vaccine Against Rabbit Hemorrhagic Disease Virus in Rabbits Document date: 2019_11_2
ID: 1apf9w7j_53
Snippet: Rabbit hemorrhagic disease (RHD) is a comparatively new and economically important viral disease that affects adult rabbits [38] . It is important to develop effective strategies for preventing and controlling the spread of RHDV. However, because there is no efficient in-vitro system for propagating RHDV, it is difficult to produce this virus as a source of vaccine antigens [39] . At present, most commercial vaccines are produced using viral prep.....
Document: Rabbit hemorrhagic disease (RHD) is a comparatively new and economically important viral disease that affects adult rabbits [38] . It is important to develop effective strategies for preventing and controlling the spread of RHDV. However, because there is no efficient in-vitro system for propagating RHDV, it is difficult to produce this virus as a source of vaccine antigens [39] . At present, most commercial vaccines are produced using viral preparations obtained from the livers of experimentally infected rabbits [40] . This strategy raises numerous concerns with respect to animal welfare and biological safety [2] . To address these issues, and to develop an effective, safe, and convenient oral vaccine against RHDV, we constructed a recombinant L. casei expressing the RHDV VP60(VP1) protein.
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