Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use Document date: 2016_9_6
ID: 0s8huajd_108
Snippet: In Pezizomycotina ascomycete fungi including Podospora anserina, frameshifting occurs near the end of a modestsized ORF that is widely conserved even to S. cerevisiae. This results in ribosomes entering a longer ORF that is less conserved and only present in Pezizomycotina. The frameshifting has been conserved for 400 million years. In most the frameshifting is into the -1 frame, and in P. anserina the shift site is U UUU UCC with a pseudoknot st.....
Document: In Pezizomycotina ascomycete fungi including Podospora anserina, frameshifting occurs near the end of a modestsized ORF that is widely conserved even to S. cerevisiae. This results in ribosomes entering a longer ORF that is less conserved and only present in Pezizomycotina. The frameshifting has been conserved for 400 million years. In most the frameshifting is into the -1 frame, and in P. anserina the shift site is U UUU UCC with a pseudoknot starting just 2 nts 3 of the shift site but with variation in the stimulatory sequence. In some, however, the frameshifting is into the +1 frame (347) .
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