Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use Document date: 2016_9_6
ID: 0s8huajd_27
Snippet: In vertebrates deeply conserved −1 frameshifting is not known to be utilized in non-mobile chromosomal expression despite the vertebrate translation machinery facilitating high efficiency viral −1 frameshifting. Exceptions are the chromosomal genes described below that are derived from mobile genes. Presumably the one now known to be essential was not always so. Given the intensity and complexity of the 'arms race' with viruses, it may mean t.....
Document: In vertebrates deeply conserved −1 frameshifting is not known to be utilized in non-mobile chromosomal expression despite the vertebrate translation machinery facilitating high efficiency viral −1 frameshifting. Exceptions are the chromosomal genes described below that are derived from mobile genes. Presumably the one now known to be essential was not always so. Given the intensity and complexity of the 'arms race' with viruses, it may mean that vertebrate cells have been unable to inhibit such −1 frameshifting, or have always used it themselves for an important function(s), or both.
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