Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use Document date: 2016_9_6
ID: 0s8huajd_65
Snippet: ZCCHC5 (also known as Mar3, Mammalian Retrotransposon-derived 3) lost its ability to retrotranspose at least 100 million years ago and contains a partial pol-like sequence. Like other similar genes, it has evolved to encode a protein beneficial for host fitness and continues to evolve under purifying selection. Many such neogenes are under epigenetic regulation, and maybe derivatives of their retrotransposon ancestor selected for cellular defense.....
Document: ZCCHC5 (also known as Mar3, Mammalian Retrotransposon-derived 3) lost its ability to retrotranspose at least 100 million years ago and contains a partial pol-like sequence. Like other similar genes, it has evolved to encode a protein beneficial for host fitness and continues to evolve under purifying selection. Many such neogenes are under epigenetic regulation, and maybe derivatives of their retrotransposon ancestor selected for cellular defense against that ancestor. ZCCHC5 has been predicted to utilize frameshifting in its expression (229) and this has been experimentally demonstrated (N.M. Wills and JFA unpublished).
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