Author: Zhao, Bing; Chen, Ye-Guang
Title: Regulation of TGF-ß Signal Transduction Document date: 2014_9_23
ID: 1ag9mnd2_23
Snippet: Furthermore, we identified Yin Yang 1 (YY1), a ubiquitously expressed transcription repressor, as a critical cooperator of Smad7 in the nucleus [101] . Although it has been reported that YY1 can attenuate TGF-/Smad signaling independently of its DNA binding ability [102] , we found that YY1 and Smad7 could interact with each other and synergistically suppress TGF--induced transcription in the nucleus. Mechanistically, Smad7 enhances the interacti.....
Document: Furthermore, we identified Yin Yang 1 (YY1), a ubiquitously expressed transcription repressor, as a critical cooperator of Smad7 in the nucleus [101] . Although it has been reported that YY1 can attenuate TGF-/Smad signaling independently of its DNA binding ability [102] , we found that YY1 and Smad7 could interact with each other and synergistically suppress TGF--induced transcription in the nucleus. Mechanistically, Smad7 enhances the interaction of YY1 with the histone deacetylase HDAC1 (Figure 4(c) ). These studies reveal the important function of Smad7 to attenuate TGF-signaling in the nucleus. This notion is supported by a recent report showing that nuclear Smad7 can promote myogenesis independent of TGF-/Smad3 signaling [103] .
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