Author: Stepanov, Grigory A.; Filippova, Julia A.; Komissarov, Andrey B.; Kuligina, Elena V.; Richter, Vladimir A.; Semenov, Dmitry V.
Title: Regulatory Role of Small Nucleolar RNAs in Human Diseases Document date: 2015_4_28
ID: 0ws5q37g_18
Snippet: One of the mechanisms regulating overall level of snoRNA in cancer cells may be the methylation of the CpG islands located close to snoRNA genes. The DNA methylation status of CpG islands within 2 kb from 5 -termini of 49 snoRNA genes was analysed in HCT-116 colorectal cancer cells [52] . Hypermethylation of the CpG islands, located near the 5 -termini of host-genes for SNORD123, SNORA70C, and SNORA59B, was established to be specific for cancer c.....
Document: One of the mechanisms regulating overall level of snoRNA in cancer cells may be the methylation of the CpG islands located close to snoRNA genes. The DNA methylation status of CpG islands within 2 kb from 5 -termini of 49 snoRNA genes was analysed in HCT-116 colorectal cancer cells [52] . Hypermethylation of the CpG islands, located near the 5 -termini of host-genes for SNORD123, SNORA70C, and SNORA59B, was established to be specific for cancer cells, compared to normal human cells. Further analysis enabled us to reveal similar DNA methylation profile close to these snoRNA host-genes in melanoma, lymphoma and leukemia cell lines, lung, breast, prostate, ovary, and kidney cancers, as well as the primary cultures of blood cells in patients with ALL. Furthermore, the expression of these box C/D and H/ACA snoRNAs in HCT-116 and SW48 cells was downregulated, compared to the cells lacking CpG island methylation near SNORD123, SNORA70C, and 59B snoRNA host-genes. The result obtained suggests the existence of epigenetic control mechanism for the regulation of snoRNA expression, which might be common for various cancer cells.
Search related documents:
Co phrase search for related documents- analysis enable and cell line: 1
- analysis enable and host gene: 1, 2
- analysis enable and human cell: 1, 2, 3
- analysis enable and ovary prostate: 1
- analysis enable and ovary prostate breast: 1
- analysis enable and ovary prostate breast lung: 1
- blood cell and cancer cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- blood cell and cell line: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39
- blood cell and control mechanism: 1
- blood cell and dna methylation: 1, 2, 3, 4, 5
- blood cell and host gene: 1, 2, 3, 4, 5, 6, 7, 8, 9
- blood cell and human cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- blood cell and kidney cancer: 1, 2
- blood cell and normal human cell: 1, 2
- blood cell and overall level: 1, 2, 3, 4
- cancer cell and cell line: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75
- cancer cell and colorectal cancer cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31
- cancer cell and control mechanism: 1, 2
- cancer cell and CpG island: 1
Co phrase search for related documents, hyperlinks ordered by date