Author: Wang, Li; Xia, Tian; Guo, Tiantian; Ru, Yi; Jiang, Yanping; Cui, Wen; Zhou, Han; Qiao, Xinyuan; Tang, Lijie; Xu, Yigang; Li, Yijing
Title: Recombinant Lactobacillus casei Expressing Capsid Protein VP60 can Serve as Vaccine Against Rabbit Hemorrhagic Disease Virus in Rabbits Document date: 2019_11_2
ID: 1apf9w7j_55
Snippet: As an oral vaccine vector, L. casei offers many advantages, such as increased safety, resistance to the harsh GI environment, robust capacity for intestinal colonization, and nonspecific immunoadjuvant effect [47] [48] [49] . Previously, live vector-based oral vaccines were constructed using LC393, a promising strain of L. casei that can deliver antigenic material to the mucosa and express numerous targeted proteins, such as VP2 protein of porcin.....
Document: As an oral vaccine vector, L. casei offers many advantages, such as increased safety, resistance to the harsh GI environment, robust capacity for intestinal colonization, and nonspecific immunoadjuvant effect [47] [48] [49] . Previously, live vector-based oral vaccines were constructed using LC393, a promising strain of L. casei that can deliver antigenic material to the mucosa and express numerous targeted proteins, such as VP2 protein of porcine parvovirus (PPV), glycoprotein E2 of bovine viral diarrhea virus (BVDV), spike protein (S) of transmissible gastroenteritis virus (TGEV), and core neutralizing epitope (COE) antigen of porcine epidemic diarrhea virus (PEDV) [35, [50] [51] [52] . Oral vaccination with these vaccines can efficiently induce mucosal, humoral, and cellular immune responses, indicating that LC393 is an excellent vector for use in oral vaccines. Therefore, LC393 was selected as a vector in the genetically engineered L. casei oral vaccine developed in our present study.
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