Author: Chuck, Chi-Pang; Chow, Hak-Fun; Wan, David Chi-Cheong; Wong, Kam-Bo
Title: Profiling of Substrate Specificities of 3C-Like Proteases from Group 1, 2a, 2b, and 3 Coronaviruses Document date: 2011_11_2
ID: 0vu7bobr_32
Snippet: Figure S1 Molecular modeling showing P3-Arg may interact with Glu-166 of 3CL pro . The model was based on the crystal structure of 3CLpro (grey) in complex with a peptide substrate 'TSAVLQQSGFRK' (yellow). P3-Val was replaced by P3-Arg using the program PyMOL. As shown, the invariant Glu-166 is in close proximity to P3-Arg, and may form favorable charge-charge interaction to P3-Arg. (TIF).....
Document: Figure S1 Molecular modeling showing P3-Arg may interact with Glu-166 of 3CL pro . The model was based on the crystal structure of 3CLpro (grey) in complex with a peptide substrate 'TSAVLQQSGFRK' (yellow). P3-Val was replaced by P3-Arg using the program PyMOL. As shown, the invariant Glu-166 is in close proximity to P3-Arg, and may form favorable charge-charge interaction to P3-Arg. (TIF)
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