Selected article for: "amino acid and human site"
Author: Kuban-Jankowska, Alicja; Sahu, Kamlesh K; Niedzialkowski, Pawel; Gorska, Magdalena; Tuszynski, Jack A; Ossowski, Tadeusz; Wozniak, Michal
Title: Redox process is crucial for inhibitory properties of aurintricarboxylic acid against activity of YopH: virulence factor of Yersinia pestis
  • Document date: 2015_7_22
    • ID: 1irvzt8v_34
    Snippet: Taking into consideration the fact that YopH has a similar amino-acid sequence in the active site as those for other PTPs [8] , including human ones, we compared the effect of ATA on human CD45 phosphatase. Protein tyrosine phosphatase CD45 is abundantly expressed in all non-nucleated haematopoietic cells and is critical for T-cell and B-cell functions. It dephosphorylates the Src kinases, therefore is important to immune-receptor modulated signa.....
    Document: Taking into consideration the fact that YopH has a similar amino-acid sequence in the active site as those for other PTPs [8] , including human ones, we compared the effect of ATA on human CD45 phosphatase. Protein tyrosine phosphatase CD45 is abundantly expressed in all non-nucleated haematopoietic cells and is critical for T-cell and B-cell functions. It dephosphorylates the Src kinases, therefore is important to immune-receptor modulated signaling. The inactivation of CD45 would lead to serious complications for the host immunity [21] . We found that ATA is more effective against YopH phosphatase than CD45.

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