Author: Zhao, Bing; Chen, Ye-Guang
Title: Regulation of TGF-ß Signal Transduction Document date: 2014_9_23
ID: 1ag9mnd2_9
Snippet: We demonstrated that PICK1 (protein that interacts with C kinase 1), opposite to c-Cbl, promotes lipid raft/caveolae localization and caveolin-mediated endocytosis of TGFreceptors [51] . As an adaptor protein, PICK1 has been shown to interact with a number of membrane proteins and regulate their subcellular trafficking, such as AMPAR [52] [53] [54] [55] , acid-sensing ion channel [56] , and ErbB2/Her-2 [57] . Our biochemical analyses reveal that .....
Document: We demonstrated that PICK1 (protein that interacts with C kinase 1), opposite to c-Cbl, promotes lipid raft/caveolae localization and caveolin-mediated endocytosis of TGFreceptors [51] . As an adaptor protein, PICK1 has been shown to interact with a number of membrane proteins and regulate their subcellular trafficking, such as AMPAR [52] [53] [54] [55] , acid-sensing ion channel [56] , and ErbB2/Her-2 [57] . Our biochemical analyses reveal that PICK1 directly interacts with the C-terminus of T RI via its PDZ domain and acts as a scaffold protein to enhance the interaction between T RI and caveolin-1, leading to increased lipid raft/caveolae localization [51] . Therefore, PICK1 increases caveolin-mediated endocytosis, ubiquitination, and degradation of T RI and suppresses TGF-signaling.
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