Author: Stepanov, Grigory A.; Filippova, Julia A.; Komissarov, Andrey B.; Kuligina, Elena V.; Richter, Vladimir A.; Semenov, Dmitry V.
Title: Regulatory Role of Small Nucleolar RNAs in Human Diseases Document date: 2015_4_28
ID: 0ws5q37g_27
Snippet: A recent study revealed that the change in box C/D RNA level also takes place in brain cells during abnormal fetal development caused by maternal alcohol consumption during pregnancy [72] . Mouse model experiments demonstrated that, along with the change in DNA methylation pattern, brain tissue also exhibited changes in expression levels of some microRNAs and snoRNAs. Particularly, the increase in SNORD115 and the decrease in SNORD116 snoRNA leve.....
Document: A recent study revealed that the change in box C/D RNA level also takes place in brain cells during abnormal fetal development caused by maternal alcohol consumption during pregnancy [72] . Mouse model experiments demonstrated that, along with the change in DNA methylation pattern, brain tissue also exhibited changes in expression levels of some microRNAs and snoRNAs. Particularly, the increase in SNORD115 and the decrease in SNORD116 snoRNA levels were demonstrated [72] . It has been previously reported that the upregulation of SNORD115 due to the duplication of the region of mouse chromosome 7 that mirrors the human chromosome 15q11-13 duplication results in abnormal brain development. The observed change in SNORD115 level led to various psychic and behavioral aberrations typical of autism [73] .
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