Selected article for: "gene expression and mRNA degradation"
Author: Narendrula, Rashmi; Mispel-Beyer, Kyle; Guo, Baoqing; Parissenti, Amadeo M.; Pritzker, Laura B.; Pritzker, Ken; Masilamani, Twinkle; Wang, Xiaohui; Lannér, Carita
Title: RNA disruption is associated with response to multiple classes of chemotherapy drugs in tumor cell lines
  • Document date: 2016_2_24
    • ID: 0mjizsoo_1
    Snippet: Control of cellular RNA degradation RNA molecules play critical roles in cells, including the facilitation of protein synthesis and regulation of gene expression. To prevent errors in the biosynthesis and function of cellular RNAs, quality control surveillance mechanisms have evolved to identify and preferentially degrade aberrant or nonfunctional RNAs. Degradation of nonfunctional RNAs occurs in regulated stages and involves specialized mechanis.....
    Document: Control of cellular RNA degradation RNA molecules play critical roles in cells, including the facilitation of protein synthesis and regulation of gene expression. To prevent errors in the biosynthesis and function of cellular RNAs, quality control surveillance mechanisms have evolved to identify and preferentially degrade aberrant or nonfunctional RNAs. Degradation of nonfunctional RNAs occurs in regulated stages and involves specialized mechanisms [1] . Mechanisms of controlled RNA degradation exist for messenger RNA (mRNA), transfer RNA (tRNA) and for ribosomal RNA (rRNA) [2] [3] [4] [5] [6] [7] [8] [9] . The active components of RNA degradation mechanisms typically include RNA-degrading enzymes or RNases, which interact with numerous co-factors (helicases, polymerases, ubiquitylases, and chaperone proteins) to provide specificity to each type of process.

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