Selected article for: "antiviral innate and innate immunity"
Author: Liu, Weiwei; Ding, Chan
Title: Roles of LncRNAs in Viral Infections
  • Document date: 2017_5_26
    • ID: 02zv1gsq_29
    Snippet: Two nuclear, highly structured and abundant viral transcripts EBER1 (167 nt) and EBER2 (172 nt) in latently EBV-infected cells are produced by EBV (Iwakiri, 2016) . EBER are polyadenylated, ncRNAs that are transcribed by RNA polymerase III (pol III) (Iwakiri, 2016) . EBERs play key roles in antiviral innate immunity via interaction with cellular proteins (Iwakiri and Takada, 2010) . EBERs are recognized by RIG-I and activate its downstream signal.....
    Document: Two nuclear, highly structured and abundant viral transcripts EBER1 (167 nt) and EBER2 (172 nt) in latently EBV-infected cells are produced by EBV (Iwakiri, 2016) . EBER are polyadenylated, ncRNAs that are transcribed by RNA polymerase III (pol III) (Iwakiri, 2016) . EBERs play key roles in antiviral innate immunity via interaction with cellular proteins (Iwakiri and Takada, 2010) . EBERs are recognized by RIG-I and activate its downstream signaling to induce expression of type-I IFNs in EBV-infected cells (Samanta et al., 2006) . Furthermore, EBERs induce IL-10 expression through IRF3, but not NF-κB activation, in BL (Burkitt's lymphoma) cells, suggesting that EBER acts as an autocrine growth factor in BL cells (Kitagawa et al., 2000; Samanta et al., 2008) . In addition, EBER also contributes to oncogenesis . For example, in BL, EBERs counteract IFN-α-induced apoptosis via binding to PKR and inhibition of its phosphorylation .

    Search related documents:
    Co phrase search for related documents
    • antiviral innate immunity and downstream signaling: 1, 2, 3, 4, 5
    • antiviral innate immunity and downstream signaling activate: 1
    • antiviral innate immunity and growth factor: 1
    • antiviral innate immunity and α induce: 1
    • antiviral innate immunity and innate immunity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
    • antiviral innate immunity and key role: 1, 2, 3, 4, 5
    • antiviral innate immunity and key role play: 1, 2
    • antiviral innate immunity and NF κB activation: 1, 2
    • antiviral innate immunity and RNA polymerase: 1, 2, 3, 4, 5
    • antiviral innate immunity and type expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • antiviral innate immunity and type expression induce: 1, 2
    • BL Burkitt lymphoma cell and BL cell: 1