Selected article for: "complete inhibition and RNA synthesis stimulate"
Author: Sun, Di; Chen, Shun; Cheng, Anchun; Wang, Mingshu
Title: Roles of the Picornaviral 3C Proteinase in the Viral Life Cycle and Host Cells
  • Document date: 2016_3_17
    • ID: 07nfb69o_17
    Snippet: Taken together, 3C pro and the precursors exhibit essential functions in viral replication. Does proteinase activity or RNA-binding activity of the 3C domain stimulate RNA synthesis? There are three distinct regions within 3C pro : the N-terminal region (K12 and R13), a central region (KFRDI86) and the C-terminal region (T153, G154 and K155) [43, 44] . Mutation (R84S/I86A) within the 3C-binding region of PV prevents stimulation of virus synthesis.....
    Document: Taken together, 3C pro and the precursors exhibit essential functions in viral replication. Does proteinase activity or RNA-binding activity of the 3C domain stimulate RNA synthesis? There are three distinct regions within 3C pro : the N-terminal region (K12 and R13), a central region (KFRDI86) and the C-terminal region (T153, G154 and K155) [43, 44] . Mutation (R84S/I86A) within the 3C-binding region of PV prevents stimulation of virus synthesis [45] and mutation (K12N/R13N) within the 3C-binding region results in normal processing of viral translation but complete inhibition of (´)strand synthesis [34] . The mechanism by which 3C pro is involved in RNA synthesis is closely related to its RNA-binding activity. Although both 3C pro and 3CD can bind to viral RNA, there are differences. A wide range of compact conformations of 3CD induced by interaction between the 3C and 3D residues exhibit more activities than 3C pro and 3D pol and these interactions are conducive to the different RNA-binding activities of 3C pro and 3CD [45] . wide range of compact conformations of 3CD induced by interaction between the 3C and 3D residues exhibit more activities than 3C pro and 3D pol and these interactions are conducive to the different RNAbinding activities of 3C pro and 3CD [45] .

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