Selected article for: "Golgi apparatus and microtubule depolymerization"
Author: Sun, Di; Chen, Shun; Cheng, Anchun; Wang, Mingshu
Title: Roles of the Picornaviral 3C Proteinase in the Viral Life Cycle and Host Cells
  • Document date: 2016_3_17
    • ID: 07nfb69o_38
    Snippet: Except for their crucial role in the replication of picornaviruses and inhibition of protein synthesis in host cells, the 3C pro s of PV and FMDV have been previously reported to mediate cleavage of microtubule-associated protein 4(MAP-4) and cause disruption of the microtubule-organizing centre (MTOC) [87, 88] . Subsequent studies have revealed that FMDV 3C pro leads to fragmentation of the Golgi apparatus, which blocks the transport of proteins.....
    Document: Except for their crucial role in the replication of picornaviruses and inhibition of protein synthesis in host cells, the 3C pro s of PV and FMDV have been previously reported to mediate cleavage of microtubule-associated protein 4(MAP-4) and cause disruption of the microtubule-organizing centre (MTOC) [87, 88] . Subsequent studies have revealed that FMDV 3C pro leads to fragmentation of the Golgi apparatus, which blocks the transport of proteins from the Golgi to the plasma membrane. Some scholars have studied the connection between Golgi fragmentation, microtubule depolymerization

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