Author: Moss, Ronald B
Title: Prospects for control of emerging infectious diseases with plasmid DNA vaccines Document date: 2009_9_7
ID: 1a5u7uux_9
Snippet: A plasmid used in DNA vaccination ( Figure 2 ) contains a gene encoding an antigen of the target pathogen (immunogen gene). Expression of the protein antigen is "turned on" in the host cell by a promoter, and "turned off" by a terminator (a polyadenylation signal sequence, generally referred to aspoly-A). Other genes such as the bacterial origin of replication sequence and an antibiotic resistance gene are incorporated for manufacturing purposes......
Document: A plasmid used in DNA vaccination ( Figure 2 ) contains a gene encoding an antigen of the target pathogen (immunogen gene). Expression of the protein antigen is "turned on" in the host cell by a promoter, and "turned off" by a terminator (a polyadenylation signal sequence, generally referred to aspoly-A). Other genes such as the bacterial origin of replication sequence and an antibiotic resistance gene are incorporated for manufacturing purposes. The resulting plasmid is a stable, self-contained unit that can be manufactured by consistent and scalable bacterial fermentation and purification processes.
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