Protective effects of fenofibrate against acute lung injury induced by intestinal ischemia/reperfusion in mice

Zhu, Qiankun; He, Guizhen; Wang, Jie; Wang, Yukang; Chen, Wei

intestinal I/R injury, the superior mesenteric artery was blocked for one hour, followed by one hour reperfusion. Serum cytokines of TNF-α , IL-1β , IL-6 and alanine aminotransferase in the sham, fenofibrate-treated and vehicle-treated groups were measured by ELISA, respectively. Data are expressed as mean ± SD (n = 6/group). *P < 0.05 vs. vehicle and # P < 0.05 vs. sham. Administration of fenofibrate improves the survival rate of mice suffered from intestinal I/R injury. Since the above results demonstrated the protective effects of fenofibrate, we therefore performed another survival experiment. Mice receiving fenofibrate intraperitoneally 60 minutes before the ischemia were compared with the control mice receiving vehicles. By observing for 24 hours, we compared the survival rate using Kaplan-Meier method and the log-rank test. Seven out of the 15 mice injected with fenofibrate were dead 24 hours post-intestinal I/R, while three of the 15 mice in the vehicle group were still alive 24 hours after intestinal I/R. In general, the survival rate in the fenofibrate group was significantly higher than that of the vehicle group (Fig. 6 ).