Author: van Zuylen, Wendy J.; Doyon, Priscilla; Clément, Jean-François; Khan, Kashif Aziz; D'Ambrosio, Lisa M.; Dô, Florence; St-Amant-Verret, Myriam; Wissanji, Tasheen; Emery, Gregory; Gingras, Anne-Claude; Meloche, Sylvain; Servant, Marc J.
Title: Proteomic Profiling of the TRAF3 Interactome Network Reveals a New Role for the ER-to-Golgi Transport Compartments in Innate Immunity Document date: 2012_7_5
ID: 1m5dbwjv_30
Snippet: In support of our findings, the ER-to-Golgi transport compartment seems to also host several proteins involved in type I IFN signalling such as TRADD [21] , the translocon [31] and potentially the exocyst [32] (Clement and Servant, unpublished observations). How these proteins cooperate with TRAF3 at the ER-to-Golgi transport compartments is currently unclear and will be the objective of future studies. Nevertheless, all these data suggest a mode.....
Document: In support of our findings, the ER-to-Golgi transport compartment seems to also host several proteins involved in type I IFN signalling such as TRADD [21] , the translocon [31] and potentially the exocyst [32] (Clement and Servant, unpublished observations). How these proteins cooperate with TRAF3 at the ER-to-Golgi transport compartments is currently unclear and will be the objective of future studies. Nevertheless, all these data suggest a model where vesicles and/or membranes originating from reorganized ER-to-Golgi compartments come in close proximity with the mitochondrial network in order to facilitate the assembly of a functional MAVS signalling complex.
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