Selected article for: "drug administration and gene expression"
Author: Stepanov, Grigory A.; Filippova, Julia A.; Komissarov, Andrey B.; Kuligina, Elena V.; Richter, Vladimir A.; Semenov, Dmitry V.
Title: Regulatory Role of Small Nucleolar RNAs in Human Diseases
  • Document date: 2015_4_28
    • ID: 0ws5q37g_37
    Snippet: Tenofovir disoproxil fumarate (TDF) is a nucleotidederived inhibitor targeted to HIV reverse transcriptase. It is allowed for administration to HIV-infected patients as part of complex antiretroviral therapy. Patients under tenofovir treatment are known to experience bone tissue loss. In a recent study Grigsby et al. have profiled gene expression in primary murine osteoclasts [97] . The research demonstrated that TDF treatment causes downregulati.....
    Document: Tenofovir disoproxil fumarate (TDF) is a nucleotidederived inhibitor targeted to HIV reverse transcriptase. It is allowed for administration to HIV-infected patients as part of complex antiretroviral therapy. Patients under tenofovir treatment are known to experience bone tissue loss. In a recent study Grigsby et al. have profiled gene expression in primary murine osteoclasts [97] . The research demonstrated that TDF treatment causes downregulation of three genes-GNAS, GOT2 and SNORD32a. It was proposed that, being combined with other cellular malfunctions, change in the snoRNA level induced by the drug administration can lead to aberrant rRNA biogenesis and induce cell death [97] .

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