Selected article for: "expression level and low expression level"
Author: Stepanov, Grigory A.; Filippova, Julia A.; Komissarov, Andrey B.; Kuligina, Elena V.; Richter, Vladimir A.; Semenov, Dmitry V.
Title: Regulatory Role of Small Nucleolar RNAs in Human Diseases
  • Document date: 2015_4_28
    • ID: 0ws5q37g_16
    Snippet: Two other genes ZFAS1 and GAS5, which host snoRNAs within their introns, have been associated with numerous types of cancers [37, [46] [47] [48] [49] . GAS5 locus contains 10 box b/D RNAs that guide modification of various nucleotides in 18S and 28S rRNAs. The expression of two GAS5-associated snoRNAs U44 and U47 was found upregulated in colorectal tumors compared to benign colon tissues [46] . Meanwhile, in breast cancer, head and neck squamous .....
    Document: Two other genes ZFAS1 and GAS5, which host snoRNAs within their introns, have been associated with numerous types of cancers [37, [46] [47] [48] [49] . GAS5 locus contains 10 box b/D RNAs that guide modification of various nucleotides in 18S and 28S rRNAs. The expression of two GAS5-associated snoRNAs U44 and U47 was found upregulated in colorectal tumors compared to benign colon tissues [46] . Meanwhile, in breast cancer, head and neck squamous cell carcinoma (SCC) low expression level of U44 directly correlated with poor survival of patients [37, 47] . ZFAS1 contains three box b/D RNAs: SNORD12, SNORD12B, and SNORD12C, that guide 2 -O-methylation of G3878 in 28S rRNA. ZFAS1 locus and these snoRNAs were shown to be strongly downregulated in breast ductal carcinoma [49] .

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