Author: Stepanov, Grigory A.; Filippova, Julia A.; Komissarov, Andrey B.; Kuligina, Elena V.; Richter, Vladimir A.; Semenov, Dmitry V.
Title: Regulatory Role of Small Nucleolar RNAs in Human Diseases Document date: 2015_4_28
ID: 0ws5q37g_36
Snippet: Tamoxifen is one of the major drugs used for the hormonotherapy of breast cancer. It serves as an estrogen receptor antagonist and induces breast cancer cell death by apoptosis [95] . However, there are breast cancer types not susceptible to tamoxifen. Global analysis of the transcriptome in tamoxifen-sensitive and tamoxifen-resistant breast cancer cells revealed differences in snoRNA pattern between the two types of cancer cells [96] . Such data.....
Document: Tamoxifen is one of the major drugs used for the hormonotherapy of breast cancer. It serves as an estrogen receptor antagonist and induces breast cancer cell death by apoptosis [95] . However, there are breast cancer types not susceptible to tamoxifen. Global analysis of the transcriptome in tamoxifen-sensitive and tamoxifen-resistant breast cancer cells revealed differences in snoRNA pattern between the two types of cancer cells [96] . Such data suggest that small nucleolar RNAs play a prominent role in sustaining drug-resistance in cancer cells, where targeted regulation of snoRNA expression may increase their sensitivity to the therapy.
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