Selected article for: "control gene and expression stability"
Author: Stepanov, Grigory A.; Filippova, Julia A.; Komissarov, Andrey B.; Kuligina, Elena V.; Richter, Vladimir A.; Semenov, Dmitry V.
Title: Regulatory Role of Small Nucleolar RNAs in Human Diseases
  • Document date: 2015_4_28
    • ID: 0ws5q37g_40
    Snippet: RNA posttranscriptional modification and control of mRNA stability and translation are important parts of gene expression regulation in human cells. Small nucleolar RNAs and their functional fragments play a considerable role in these processes: they guide modification of rRNA and snRNA nucleotides, influence alternative splicing of complementary pre-mRNAs, and control translation and stability of mRNAs through RISC-dependent pathway. Disruption .....
    Document: RNA posttranscriptional modification and control of mRNA stability and translation are important parts of gene expression regulation in human cells. Small nucleolar RNAs and their functional fragments play a considerable role in these processes: they guide modification of rRNA and snRNA nucleotides, influence alternative splicing of complementary pre-mRNAs, and control translation and stability of mRNAs through RISC-dependent pathway. Disruption of snoRNA expression can be caused by both external factors and intracellular signal cascades and result in physiological changes on a cellular level, organ dysfunctions, and various diseases. The structure of snoRNAs, their expression pattern, and localization within cells have regulatory significance and are considered diagnostic markers of pathology. The insight into snoRNA expression and the mechanisms of their functioning will provide new possibilities for the development of diagnostic systems and novel therapeutic approaches for human diseases.

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