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Author: Guo, Jiao; Jia, Xiaoying; Liu, Yang; Wang, Shaobo; Cao, Junyuan; Zhang, Bo; Xiao, Gengfu; Wang, Wei
Title: Screening of Natural Extracts for Inhibitors against Japanese Encephalitis Virus Infection
  • Document date: 2020_2_21
  • ID: 161ck1i9_15
    Snippet: Together, these findings provide valuable information that may be used in future clinical trials examining the effects of ouabain on JEV infection. Moreover, our results indicate that ATPase is a promising pharmacological target in JEV infection. administered with ouabain at 3 mg/kg of body weight or a vehicle control every day for 21 consecutive days. Mice were sacrificed at day 1, 3, 7, 10, or 21, depending on the experimental design. Blood, sp.....
    Document: Together, these findings provide valuable information that may be used in future clinical trials examining the effects of ouabain on JEV infection. Moreover, our results indicate that ATPase is a promising pharmacological target in JEV infection. administered with ouabain at 3 mg/kg of body weight or a vehicle control every day for 21 consecutive days. Mice were sacrificed at day 1, 3, 7, 10, or 21, depending on the experimental design. Blood, spleen, and brain samples were collected for plaque assay, qRT-PCR, and histopathology investigation (Vectra ss; PerkinElmer).

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