Selected article for: "negative sense and nucleocapsid protein"
Author: Nunes, Márcio Roberto Teixeira; de Souza, William Marciel; Acrani, Gustavo Olszanski; Cardoso, Jedson Ferreira; da Silva, Sandro Patroca; Badra, Soraya Jabur; Figueiredo, Luiz Tadeu Moraes; Vasconcelos, Pedro Fernando da Costa
Title: Revalidation and genetic characterization of new members of Group C (Orthobunyavirus genus, Peribunyaviridae family) isolated in the Americas
  • Document date: 2018_5_24
    • ID: 17f1evh3_3
    Snippet: The genomes of members of Group C viruses presents the typical organization of other orthobunyaviruses, which are a tri-segmented negative-sense RNA named small (SRNA), medium (MRNA) and large (LRNA) segments. The SRNA encodes a nucleocapsid protein (N protein) and a non-structural protein (NSs), while the MRNA encodes a polyprotein precursor that after a post-cleavage process gives rise to two envelope glycoproteins (Gc and Gn) and a non-structu.....
    Document: The genomes of members of Group C viruses presents the typical organization of other orthobunyaviruses, which are a tri-segmented negative-sense RNA named small (SRNA), medium (MRNA) and large (LRNA) segments. The SRNA encodes a nucleocapsid protein (N protein) and a non-structural protein (NSs), while the MRNA encodes a polyprotein precursor that after a post-cleavage process gives rise to two envelope glycoproteins (Gc and Gn) and a non-structural protein (NSm). LRNA segment encodes a large RNA-dependent RNA polymerase (RdRp) [7] . So far, previous studies have described the genomic characteristics S and M RNA segments of members of Group C viruses, but many sequences generated by Sanger sequencing approach were divergent, despite using the same strains of group C viruses [1, [7] [8] [9] . Therefore, in this study, we combined high-throughput sequencing (HTS), rapid amplifica-

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