Author: Hershenson, Marc B.
Title: Rhinovirus-Induced Exacerbations of Asthma and COPD Document date: 2013_2_21
ID: 1kdc6xk8_27
Snippet: Viral infection may also attenuate the antibacterial innate immune response in COPD. For example, rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages. We have shown that RV infection of mucociliary-differentiated airway epithelial cells cultured at air-liquid interface causes barrier dysfunction which allows translocation of Haemophilus influenzae across the epithelium [69] . We have also shown that el.....
Document: Viral infection may also attenuate the antibacterial innate immune response in COPD. For example, rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages. We have shown that RV infection of mucociliary-differentiated airway epithelial cells cultured at air-liquid interface causes barrier dysfunction which allows translocation of Haemophilus influenzae across the epithelium [69] . We have also shown that elastase-and LPS-treated mice with a lung phenotype similar to COPD show delayed clearance of rhinovirus in vivo, similar to humans with COPD [71] .
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