Selected article for: "animal model and recent study"
Author: Zhai, Shao-Lun; Lu, Shou-Sheng; Wei, Wen-Kang; Lv, Dian-Hong; Wen, Xiao-Hui; Zhai, Qi; Chen, Qin-Ling; Sun, Yan-Wei; Xi, Yun
Title: Reservoirs of Porcine Circoviruses: A Mini Review
  • Document date: 2019_9_19
    • ID: 1e8qah7d_7
    Snippet: Seroconversion of PCV1 antibody was detected in several murine species including NMRI, BALB/c, and Black C57 (14) . Based on evidence from numerous studies, mice are often considered important animal models of PCV2 infection (26) (27) (28) (29) (30) (31) (32) (33) (34) (35) . However, only a few studies have conformed PCV infection in field rodent samples. Since 2010, several research teams from Hungary, Brazil, Korea and China have provided mole.....
    Document: Seroconversion of PCV1 antibody was detected in several murine species including NMRI, BALB/c, and Black C57 (14) . Based on evidence from numerous studies, mice are often considered important animal models of PCV2 infection (26) (27) (28) (29) (30) (31) (32) (33) (34) (35) . However, only a few studies have conformed PCV infection in field rodent samples. Since 2010, several research teams from Hungary, Brazil, Korea and China have provided molecular evidence of PCV2 in rodents circulating on swine farms (36) (37) (38) (39) . In the study from Brazil, PCV2 antigen was identified in the spleen, lungs and kidneys of rodent species Mus musculus and Rattus rattus using immunohistochemistry assay (37) . In addition, rodent-origin PCV2 genome sequences had remarkable similarity with gene sequences of PCV2 isolated from pigs (37, 39) . It is noteworthy that one recent study identified PCV3 in commercially sourced laboratory mice including BALB/c and ICR mice (40) . This is in contrast with from the Hungarian study, which claims that rodents need certain contact with pigs, without which PCV2 is negative in rodents (36) . Owing to limited information, we are currently unable to ascertain the origin of murine PCV3 in laboratory mice. Without significant clinical manifestation, rodents are more of a carrying reservoir and an animal model of PCVs. On farms, unconstrained rodents may promote the spread of PCVs.

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