Selected article for: "autophagy activity and nuclear translocation"
Author: Shenglan Shang; Jiaqi Wu; Xiaoli Li; Xin Liu; Pan Li; Chunli Zheng; Yonghua Wang; Songqing Liu; Jiang Zheng; Hong Zhou
Title: Artesunate interacts with Vitamin D receptor to reverse mouse model of sepsis-induced immunosuppression via enhancing autophagy
  • Document date: 2020_2_27
    • ID: egntml7e_93
    Snippet: Mechanically, AS exerts its "pro-inflammatory" effect in immunosuppression stage in contrast to its "anti-inflammatory" effect in cytokines storm stage. Our present results outline the mechanism of AS's effect through two ways (presented in Figure 8 ): AS interacted with VDR to prevent the nuclear translocation of VDR and then decreases its negative regulation of autophagy related target genes such as ATG16L1, and then increases autophagy activit.....
    Document: Mechanically, AS exerts its "pro-inflammatory" effect in immunosuppression stage in contrast to its "anti-inflammatory" effect in cytokines storm stage. Our present results outline the mechanism of AS's effect through two ways (presented in Figure 8 ): AS interacted with VDR to prevent the nuclear translocation of VDR and then decreases its negative regulation of autophagy related target genes such as ATG16L1, and then increases autophagy activity.

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