Author: Ahanchian, Hamid; Jones, Carmen M; Chen, Yueh-sheng; Sly, Peter D
Title: Respiratory viral infections in children with asthma: do they matter and can we prevent them? Document date: 2012_9_13
ID: 0mnsm6s4_52
Snippet: Prevention of attachment, entry and uncoating HRV deposits on nasal or conjunctival mucosa and is transported to the posterior nasopharynx by mucociliary action of epithelial cells [172] . The so-called major group of HRV uses intercellular adhesion molecule-1 (ICAM-1) as their receptor [173] and the minor group attach to low density lipoprotein (LDL) receptor and very-LDL (VLDL) receptors on epithelial cells in the adenoid area to bind and enter.....
Document: Prevention of attachment, entry and uncoating HRV deposits on nasal or conjunctival mucosa and is transported to the posterior nasopharynx by mucociliary action of epithelial cells [172] . The so-called major group of HRV uses intercellular adhesion molecule-1 (ICAM-1) as their receptor [173] and the minor group attach to low density lipoprotein (LDL) receptor and very-LDL (VLDL) receptors on epithelial cells in the adenoid area to bind and enter cells [174, 175] . Viral attachment can be prevented by specific anti-HRV neutralizing antibodies, anti-receptor antibodies and soluble receptor molecules.
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