Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use Document date: 2016_9_6
ID: 0s8huajd_131
Snippet: The identity of the 3 nucleotides, GGG, 3 of the HIV shift site codon UUA are important for frameshifting efficiency, and it has been proposed that a part of the frameshifting to give the Leu-containing product occurs while the GGG is in the (perhaps distorted) A-site (405) . The umbravirus, pea enation mosaic virus, shift site 5 G GAU UUU ( UGG UAG) has a stop codon 3 nts 3 of it. Changing the UAG to another stop has no effect on frameshifting b.....
Document: The identity of the 3 nucleotides, GGG, 3 of the HIV shift site codon UUA are important for frameshifting efficiency, and it has been proposed that a part of the frameshifting to give the Leu-containing product occurs while the GGG is in the (perhaps distorted) A-site (405) . The umbravirus, pea enation mosaic virus, shift site 5 G GAU UUU ( UGG UAG) has a stop codon 3 nts 3 of it. Changing the UAG to another stop has no effect on frameshifting but changing it to a sense codon has a drastic effect that is not attributable to effects on a 3 structure (406) .
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