Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use Document date: 2016_9_6
ID: 0s8huajd_153
Snippet: The key feature of this control mechanism is a metabolite, polyamines, binding to a nascent autoregulatory sensor protein to regulate the decoding of its own mRNA. One aspect of its relevance to the non-budding yeast cases considered next is that polyamine binding assays done in parallel with S. cerevisiae antizyme shows that human antizyme 1 also directly binds polyamines. So even where the intrinsic level of frameshifting is much lower and stim.....
Document: The key feature of this control mechanism is a metabolite, polyamines, binding to a nascent autoregulatory sensor protein to regulate the decoding of its own mRNA. One aspect of its relevance to the non-budding yeast cases considered next is that polyamine binding assays done in parallel with S. cerevisiae antizyme shows that human antizyme 1 also directly binds polyamines. So even where the intrinsic level of frameshifting is much lower and stimulators rather than inhibitors are used, direct binding of polyamines to nascent peptide has the potential to be generally important for the regulatory aspect.
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