Author: Ahanchian, Hamid; Jones, Carmen M; Chen, Yueh-sheng; Sly, Peter D
Title: Respiratory viral infections in children with asthma: do they matter and can we prevent them? Document date: 2012_9_13
ID: 0mnsm6s4_56
Snippet: Despite extensive research, no agent has been approved for prevention and/or therapy of rhinovirus-induced diseases so far. Ruprintrivir selectively inhibits HRV 3C protease and shows potent, broad-spectrum anti-HRV activity in vitro. Ruprintrivir nasal spray (2% solution) prophylaxis reduced the proportion of subjects with positive viral culture by 26% and reduce viral titers, but did not decrease the frequency of colds [181] . HRV RNA synthesis.....
Document: Despite extensive research, no agent has been approved for prevention and/or therapy of rhinovirus-induced diseases so far. Ruprintrivir selectively inhibits HRV 3C protease and shows potent, broad-spectrum anti-HRV activity in vitro. Ruprintrivir nasal spray (2% solution) prophylaxis reduced the proportion of subjects with positive viral culture by 26% and reduce viral titers, but did not decrease the frequency of colds [181] . HRV RNA synthesis during replication can be blocked by deoxyribozymes [182] , morpholino oligomers [183] , and small interfering ribonucleic acids [184] . The novel antiviral therapies that have been discovered recently, may one day add significantly to the armamentarium of antiviral agents, against respiratory viral infections in asthmatic children.
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