Selected article for: "activator inhibitor and acute sars respiratory syndrome"
Author: Zhao, Bing; Chen, Ye-Guang
Title: Regulation of TGF-ß Signal Transduction
  • Document date: 2014_9_23
    • ID: 1ag9mnd2_21
    Snippet: Smad4 is the common Smad critical for both TGF-/activin and BMP signaling. However, several studies have also revealed Smad4-independent R-Smad signaling [94] [95] [96] . Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein (SARS-CoV N protein) is a 46 kDa viral RNA-binding protein that shares little homology with the N proteins of other known coronaviruses [97] . We found that SARS-CoV N interacts with Smad3 and enhances.....
    Document: Smad4 is the common Smad critical for both TGF-/activin and BMP signaling. However, several studies have also revealed Smad4-independent R-Smad signaling [94] [95] [96] . Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein (SARS-CoV N protein) is a 46 kDa viral RNA-binding protein that shares little homology with the N proteins of other known coronaviruses [97] . We found that SARS-CoV N interacts with Smad3 and enhances Smad3-p300 interaction, which specifically potentiates the Smad3mediated transcriptional responses of TGF-such as the expression of plasminogen activator inhibitor-1 (PAI-1) [98] . At the same time, the SARS-CoV N interferes with the complex formation between Smad3 and Smad4 and inhibits TGF--induced Smad4-mediated proapoptotic genes expression and cell apoptosis (Figure 4(a) ).

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