Author: Stepanov, Grigory A.; Filippova, Julia A.; Komissarov, Andrey B.; Kuligina, Elena V.; Richter, Vladimir A.; Semenov, Dmitry V.
Title: Regulatory Role of Small Nucleolar RNAs in Human Diseases Document date: 2015_4_28
ID: 0ws5q37g_13
Snippet: Small nucleolar box H/ACA RNA SNORA42, which is overexpressed in nonsmall cell lung carcinoma (NSCLC), was identified as a lung cancer oncogene [38] . siRNA knockdown of SNORA42 results in reduced cancer cell growth (H460 and H1944 cells), inhibited H460 and H1944 cell colony formation, and compromised tumorigenicity in animal models. Specific SNORA42 suppression in cancer cells leads to apoptosis in a p53-dependent manner. On the contrary, overe.....
Document: Small nucleolar box H/ACA RNA SNORA42, which is overexpressed in nonsmall cell lung carcinoma (NSCLC), was identified as a lung cancer oncogene [38] . siRNA knockdown of SNORA42 results in reduced cancer cell growth (H460 and H1944 cells), inhibited H460 and H1944 cell colony formation, and compromised tumorigenicity in animal models. Specific SNORA42 suppression in cancer cells leads to apoptosis in a p53-dependent manner. On the contrary, overexpression of SNORA42 activates cancer cell growth. The expression level of SNORA42 in lung tumor tissue specimen was found to be inversely correlated with the survival of NSCLC patients [38] .
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