Selected article for: "acute lymphoblastic and cell line"
Author: Stepanov, Grigory A.; Filippova, Julia A.; Komissarov, Andrey B.; Kuligina, Elena V.; Richter, Vladimir A.; Semenov, Dmitry V.
Title: Regulatory Role of Small Nucleolar RNAs in Human Diseases
  • Document date: 2015_4_28
    • ID: 0ws5q37g_17
    Snippet: SnoRNA expression level was found decreased in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) cells, compared to normal cells [50] . Underexpression has been reported for another class of ncRNAs, microRNAs, in several types of cancers [50, 51] . However, a few snoRNAs are overexpressed in some AML cases. Specific overexpression has been reported for several orphan box C/D RNAs: SNORD112-114, encoded within the DLK1-Dio3 locus.....
    Document: SnoRNA expression level was found decreased in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) cells, compared to normal cells [50] . Underexpression has been reported for another class of ncRNAs, microRNAs, in several types of cancers [50, 51] . However, a few snoRNAs are overexpressed in some AML cases. Specific overexpression has been reported for several orphan box C/D RNAs: SNORD112-114, encoded within the DLK1-Dio3 locus of chromosome 14. SNORD114-1 has been shown to promote cell cycle progression through G0/G1 to S phase transition [50] . Overexpression of SNORD114-1 activates proliferation in K562 cell line, while targeted suppression of the box C/D RNA leads to the induction of cell death. The data implicate that some of these box C/D RNAs participate in the development of leukemia.

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