Selected article for: "antizyme frameshifting and shift site"

Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use
  • Document date: 2016_9_6
  • ID: 0s8huajd_169
    Snippet: Though eukaryotes do not have Shine Dalgarno interactions, an mRNA sequence 5 of the shift site in many antizyme genes acts directly to stimulate antizyme frameshifting (264, 270) . There is substantial evidence that it acts at the mRNA level without intra-mRNA pairing, though cryoEM information would be invaluable. Independent from this, there is suggestive evidence for mRNA: rRNA pairing within 80S ribosomes in some cases of initiation/reinitia.....
    Document: Though eukaryotes do not have Shine Dalgarno interactions, an mRNA sequence 5 of the shift site in many antizyme genes acts directly to stimulate antizyme frameshifting (264, 270) . There is substantial evidence that it acts at the mRNA level without intra-mRNA pairing, though cryoEM information would be invaluable. Independent from this, there is suggestive evidence for mRNA: rRNA pairing within 80S ribosomes in some cases of initiation/reinitiation (497-500) and shunting (501, 502) .

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