Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use Document date: 2016_9_6
ID: 0s8huajd_32
Snippet: Notable also was the novel distal stimulatory element discovered by W. Allen Miller and colleagues from study of the frameshifting utilized by the luteovirus, barley yellow dwarf virus. This led to the attractive proposal that the frameshifting utilized by some RNA viruses to synthesize their polymerase is part of a 'traffic control' strategy. The newly synthesized RNA-dependent RNA polymerase proceeds from the 3 end to synthesize negative strand.....
Document: Notable also was the novel distal stimulatory element discovered by W. Allen Miller and colleagues from study of the frameshifting utilized by the luteovirus, barley yellow dwarf virus. This led to the attractive proposal that the frameshifting utilized by some RNA viruses to synthesize their polymerase is part of a 'traffic control' strategy. The newly synthesized RNA-dependent RNA polymerase proceeds from the 3 end to synthesize negative strands and soon disrupts the long distance pairing of the frameshifting recoding signals. Not only does this greatly reduce synthesis of now unneeded further polymerase, it frees the polymerase coding sequence for polymerase progression unhindered by oncoming ribosomes (110) .
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