Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use Document date: 2016_9_6
ID: 0s8huajd_233
Snippet: A surprise for some early practitioners of phage display was that some active encoding sequences had frame disruptions. For instance, biopanning of a random peptide library on a filamentous phage for sequences that would bind to a growth hormone binding protein yielded sequences whose decoding was deduced to undergo substantial levels of either +1 or −1 frameshifting (645), and corresponding results have been seen in other phage display studies.....
Document: A surprise for some early practitioners of phage display was that some active encoding sequences had frame disruptions. For instance, biopanning of a random peptide library on a filamentous phage for sequences that would bind to a growth hormone binding protein yielded sequences whose decoding was deduced to undergo substantial levels of either +1 or −1 frameshifting (645), and corresponding results have been seen in other phage display studies (646, 647) . Recent systematic exploration of shift-prone sequences in E. coli (195) , and searches in other bacteria (198) is relevant to the anticipation, and understanding of, such results.
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