Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice

Tchitchek, Nicolas; Eisfeld, Amie J; Tisoncik-Go, Jennifer; Josset, Laurence; Gralinski, Lisa E; Bécavin, Christophe; Tilton, Susan C; Webb-Robertson, Bobbie-Jo; Ferris, Martin T; Totura, Allison L; Li, Chengjun; Neumann, Gabriele; Metz, Thomas O; Smith, Richard D; Waters, Katrina M; Baric, Ralph; Kawaoka, Yoshihiro; Katze, Michael G

Throughout this article, we use the following definitions to describe the different conditions: (i) biological condition refers to all samples infected by the same virus, at the same inoculation dose, and from the same dpi; (ii) dosage condition refers to samples infected by the same virus and at the same inoculation dose; (iii) strain condition refers to all samples infected by the same virus. Based on these criteria, the dataset is divided into 51 transcriptomic biological conditions and 42 proteomic biological conditions, representing 13 transcriptomic and 11 proteomic dosage conditions, and 6 strain conditions. Additional file 1: Figure S1 provides a schematic representation of the collected infected 'omics profiles across the time course.