Author: Zhu, Zheng; Chan, Jasper Fuk-Woo; Tee, Kah-Meng; Choi, Garnet Kwan-Yue; Lau, Susanna Kar-Pui; Woo, Patrick Chiu-Yat; Tse, Herman; Yuen, Kwok-Yung
Title: Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic Document date: 2016_3_16
ID: 1hmte4la_18
Snippet: Although ZIKV was estimated to have emerged between 1892 and 1943 by Bayesian evolutionary analysis and has been isolated for nearly 70 years, very little is known about the virology of this emerging virus. 60 In this study, we summarized its genomic changes with a limited number of virus strains. These virus strains included both the pre-epidemic African and Asian lineage strains that were mostly mosquito isolates, and the epidemic strains found.....
Document: Although ZIKV was estimated to have emerged between 1892 and 1943 by Bayesian evolutionary analysis and has been isolated for nearly 70 years, very little is known about the virology of this emerging virus. 60 In this study, we summarized its genomic changes with a limited number of virus strains. These virus strains included both the pre-epidemic African and Asian lineage strains that were mostly mosquito isolates, and the epidemic strains found in human. Among these virus strains, we have detected a number of amino acid substitutions throughout the genome and a conformational change in the SLI structure at the 3ʹ-UTR of the epidemic ZIKV strain. We have also detected a possible recombination of a NS2B fragment between the Asian lineage of ZIKV and SPOV. The impact of these changes of the virus genome on the virulence, viability and transmissibility of ZIKV should be further investigated in biological assays.
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