Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use Document date: 2016_9_6
ID: 0s8huajd_83
Snippet: Before the second and more conserved antizyme gene, antizyme 2 (294), was identified as encoding an antizyme, it was recognized as one of a very small number of genes upregulated by a seizure-inducing substrate in neuronal cells (295) . Antizyme 2 protein is phosphorylated and is localized more in the nucleus than is antizyme 1 (296) . While antizyme 1 has nuclear import and export signals, part of which is encoded by its ORF1, it is the C-termin.....
Document: Before the second and more conserved antizyme gene, antizyme 2 (294), was identified as encoding an antizyme, it was recognized as one of a very small number of genes upregulated by a seizure-inducing substrate in neuronal cells (295) . Antizyme 2 protein is phosphorylated and is localized more in the nucleus than is antizyme 1 (296) . While antizyme 1 has nuclear import and export signals, part of which is encoded by its ORF1, it is the C-terminal region of antizyme 2 that is involved in its nuclear translocation perhaps by association with another protein that does have a nuclear localization signal (296) . Forced expression of at least antizyme 1 has strong tumor suppressive properties (297) .
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