Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use Document date: 2016_9_6
ID: 0s8huajd_92
Snippet: Ribosome profiling has the potential to reveal frameshifting candidates, and the Supplementary Material of a classic paper on such profiling of E. coli identified copA as a candidate for a 'novel translational event' (312) . Follow-up analysis revealed that efficient −1 ribosomal frameshifting does occur and yields a 70 amino acid product which is a putative copper chaperone (S. Meydan, A. Mankin, N. Vazquez-Laslop, personal communication), muc.....
Document: Ribosome profiling has the potential to reveal frameshifting candidates, and the Supplementary Material of a classic paper on such profiling of E. coli identified copA as a candidate for a 'novel translational event' (312) . Follow-up analysis revealed that efficient −1 ribosomal frameshifting does occur and yields a 70 amino acid product which is a putative copper chaperone (S. Meydan, A. Mankin, N. Vazquez-Laslop, personal communication), much shorter than the 834 AA product of standard zero-frame decoding.
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