Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use Document date: 2016_9_6
ID: 0s8huajd_79
Snippet: In addition to the competitive inhibition that all antizymes exert on formation of active ornithine decarboxylase dimers, as shown by many studies (260), antizyme 1 also negatively controls polyamine extracellular uptake via receptor interaction (278, 279) , and promotes polyamine secretion (280) . In Filarial roundworm parasites there is no functional ornithine decarboxylase but still an antizyme whose function, at least in part, is likely for r.....
Document: In addition to the competitive inhibition that all antizymes exert on formation of active ornithine decarboxylase dimers, as shown by many studies (260), antizyme 1 also negatively controls polyamine extracellular uptake via receptor interaction (278, 279) , and promotes polyamine secretion (280) . In Filarial roundworm parasites there is no functional ornithine decarboxylase but still an antizyme whose function, at least in part, is likely for regulating polyamine uptake (281) . Antizyme 1 is in turn subject to inactivation by antizyme inhibitory proteins, e.g. (282) and (283-285) whose synthesis is governed via uORFs by polyamines (286) .
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