Author: Narendrula, Rashmi; Mispel-Beyer, Kyle; Guo, Baoqing; Parissenti, Amadeo M.; Pritzker, Laura B.; Pritzker, Ken; Masilamani, Twinkle; Wang, Xiaohui; Lannér, Carita
Title: RNA disruption is associated with response to multiple classes of chemotherapy drugs in tumor cell lines Document date: 2016_2_24
ID: 0mjizsoo_6
Snippet: In the current study, we describe for the first time an in vitro cell model system for the study of chemotherapydependent RNA disruption. This included an investigation into the relationship between RNA disruption, drug type, drug dose, and drug incubation time. We also examined whether RNA disruption reflected the sensitivity of cells to various drugs (previously measured using the clonogenic assay). In addition, we explored the origins of the r.....
Document: In the current study, we describe for the first time an in vitro cell model system for the study of chemotherapydependent RNA disruption. This included an investigation into the relationship between RNA disruption, drug type, drug dose, and drug incubation time. We also examined whether RNA disruption reflected the sensitivity of cells to various drugs (previously measured using the clonogenic assay). In addition, we explored the origins of the rRNA fragments and the temporal relationship between the induction of apoptosis by docetaxel, as measured by enhanced caspase activity and annexin V staining, and RNA disruption. Finally, we show that inhibition of caspase-3 activity reduces, but does not eliminate, RNA disruption in response to docetaxel.
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