Author: Schwarz, Megan C.; Sourisseau, Marion; Espino, Michael M.; Gray, Essanna S.; Chambers, Matthew T.; Tortorella, Domenico; Evans, Matthew J.
Title: Rescue of the 1947 Zika Virus Prototype Strain with a Cytomegalovirus Promoter-Driven cDNA Clone Document date: 2016_9_28
ID: 0i1abjfa_18
Snippet: Growth curves initiated at a range of MOIs also demonstrated comparable growth kinetics between the rescued and parental viruses (data not shown). These results are in stark contrast to previously published multicycle growth curve results with the 2010 Cambodia and 2015 Brazil ZIKV rescued viruses, which exhibited approximately 10-to 's t test) . 50-fold slower spread than their respective parental isolates. Therefore, although extended plaque as.....
Document: Growth curves initiated at a range of MOIs also demonstrated comparable growth kinetics between the rescued and parental viruses (data not shown). These results are in stark contrast to previously published multicycle growth curve results with the 2010 Cambodia and 2015 Brazil ZIKV rescued viruses, which exhibited approximately 10-to 's t test) . 50-fold slower spread than their respective parental isolates. Therefore, although extended plaque assays indicate that our rescued MR766 virus may exhibit some attenuation in comparison to the parental MR766 isolate, its replication characteristics are closer to those of its parental isolate than to the 2010 Cambodia and 2015 Brazil ZIKV rescued viruses.
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