Risk factors and patterns of household clusters of respiratory viruses in rural Nepal

Scott, E. M.; Magaret, A.; Kuypers, J.; Tielsch, J. M.; Katz, J.; Khatry, S. K.; Stewart, L.; Shrestha, L.; LeClerq, S. C.; Englund, J. A.; Chu, H. Y.

Of 362 households contributing to the regression analysis of any virus transmission, 52 households included more than one mother-infant pair. Within households with multiple mothers, there was 100% agreement in reporting of electricity within the home, 89% agreement in indoor cookstove use and 85% agreement of latrine within the home. The multivariable regression model was performed using the alternative mother's household information with similar results (Supplementary Table S1 ). A sensitivity analysis was also performed using a definition of transmission as a secondary case of the same virus within 28 days of initial infection within the household. Using this definition, preschool child index case, coinfection as initial infection and a low birthweight infant in the household were associated with an increased incidence of household transmission (Supplementary Tables S2 and S3 ).