Author: Liu, Weiwei; Ding, Chan
Title: Roles of LncRNAs in Viral Infections Document date: 2017_5_26
ID: 02zv1gsq_17
Snippet: LncRNA#32 is 2,946 nt in length and was identified after poly I: C stimulation. The silencing of lncRNA#32 remarkably reduced the level of ISG expression, such as IRF7 and OASL, resulting in sensitivity to encephalomyocarditis virus (EMCV) infection. In contrast, overexpression of lncRNA#32 significantly inhibited EMCV replication. LncRNA#32 interacts with hnRNPU and ATF2 to regulate ISG expression (Nishitsuji et al., 2016) . These results sugges.....
Document: LncRNA#32 is 2,946 nt in length and was identified after poly I: C stimulation. The silencing of lncRNA#32 remarkably reduced the level of ISG expression, such as IRF7 and OASL, resulting in sensitivity to encephalomyocarditis virus (EMCV) infection. In contrast, overexpression of lncRNA#32 significantly inhibited EMCV replication. LncRNA#32 interacts with hnRNPU and ATF2 to regulate ISG expression (Nishitsuji et al., 2016) . These results suggested that LncRNA#32 was involved in anti-viral responses by controlling ISG expression.
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