Author: Tchitchek, Nicolas; Eisfeld, Amie J; Tisoncik-Go, Jennifer; Josset, Laurence; Gralinski, Lisa E; Bécavin, Christophe; Tilton, Susan C; Webb-Robertson, Bobbie-Jo; Ferris, Martin T; Totura, Allison L; Li, Chengjun; Neumann, Gabriele; Metz, Thomas O; Smith, Richard D; Waters, Katrina M; Baric, Ralph; Kawaoka, Yoshihiro; Katze, Michael G
Title: Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice Document date: 2013_7_29
ID: 1qc72ovc_50
Snippet: To determine Median Lethal Dose values (MLD) for VN1203-WT and mutants, we infected 6-week-old BALB/C mice with serial dilutions of each virus (3 mice per dilution) and monitored individual mouse body weight loss and survival over 14 days. All mice were humanely euthanized either when exhibiting severe clinical symptoms, or at the end of the 14 day observation period. MLD values were calculated according to the method of Reed and Muench [46] ......
Document: To determine Median Lethal Dose values (MLD) for VN1203-WT and mutants, we infected 6-week-old BALB/C mice with serial dilutions of each virus (3 mice per dilution) and monitored individual mouse body weight loss and survival over 14 days. All mice were humanely euthanized either when exhibiting severe clinical symptoms, or at the end of the 14 day observation period. MLD values were calculated according to the method of Reed and Muench [46] .
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