Author: Narendrula, Rashmi; Mispel-Beyer, Kyle; Guo, Baoqing; Parissenti, Amadeo M.; Pritzker, Laura B.; Pritzker, Ken; Masilamani, Twinkle; Wang, Xiaohui; Lannér, Carita
Title: RNA disruption is associated with response to multiple classes of chemotherapy drugs in tumor cell lines Document date: 2016_2_24
ID: 0mjizsoo_39
Snippet: We further observed that RNA disruption is both dose-and time-dependent (Figs. 1 and 2) . Moreover, the extent of RNA disruption closely reflects cellular sensitivity to chemotherapy agents (Fig. 5) . RNA disruption was observed to occur only in cell lines demonstrated to have sensitivity to chemotherapy agents (as measured using clonogenic assays) with no RNA disruption being observed in derivative cell lines exhibiting resistance to these agent.....
Document: We further observed that RNA disruption is both dose-and time-dependent (Figs. 1 and 2) . Moreover, the extent of RNA disruption closely reflects cellular sensitivity to chemotherapy agents (Fig. 5) . RNA disruption was observed to occur only in cell lines demonstrated to have sensitivity to chemotherapy agents (as measured using clonogenic assays) with no RNA disruption being observed in derivative cell lines exhibiting resistance to these agents (Fig. 5) . We also show in this study that there is a temporal relationship between induction of apoptosis by docetaxel in A2780 cells and RNA disruption by this agent.
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